Mounjaro vs Ozempic: What is the difference between these two diabetes and weight loss pills?

Weight problems is a world pandemic. In line with the World Well being Group (WHO), grownup weight problems worldwide greater than doubled between 1990 and 2022. This has led to extra well being points, together with heart problems, diabetes, neuropathy, persistent respiratory illness, and digestive points. Sustaining a wholesome weight is a significant concern on this state of affairs. Nevertheless, pursuing weight reduction rapidly leads folks to search out drug options aimed toward managing diabetes, which additionally results in weight reduction. Ozempic and Mounjaro are two such weight reduction medicine which have triggered agitation worldwide. Are they comparable or totally different? Let’s break down the dialogue of Ozempic and Munjaro for you!

How does Mounjaro work?

Mounjaro (Tirzepatide) is a brand new injectable agent developed for the therapy of kind 2 diabetes, however can also be used as a weight reduction drug. “It’s a twin glucose-dependent insulintropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist,” says diabetic Dr. Shankar Kumar Venkatarayaraju. Subsequently, it mimics the consequences of each GIP and GLP-1 hormones, which management blood glucose ranges, cut back urge for food, and results in weight reduction.

Medicine obtainable with prefilled pen are administered as soon as per week through subcutaneous injection. That’s, it’s injected underneath the pores and skin of the stomach, thighs, or higher arms. It has been authorized by the US Meals and Drug Administration for kind 2 diabetes and is used off-label for weight problems.

How does Ozempic work?

Ozempic (Semaglutide) is a weekly injectable treatment devoted to kind 2 diabetes administration, and is used off-label for weight reduction. “It’s a GLP-1 receptor agonist that mimics endogenous glucagon-like peptide-1,” specialists share. It helps elevate ranges of intestinal hormone, Incletin, and produce extra insulin if vital. It additionally helps cut back the quantity of sugar produced by the liver, slowing down meals digestion. These mechanisms assist decrease blood sugar ranges and contribute to weight reduction.

Mounjaro vs Ozempic: What are the similarities?

Each medicine are comparable in a number of methods.

1. Weight reduction shouldn’t be authorized

Mounjaro has not been authorized for weight reduction by the FDA, regardless of its lively ingredient, tilzepatide, which has obtained a inexperienced sign for weight reduction underneath the model identify Zepbound. Equally, Ozempic shouldn’t be authorized for this goal. It’s Wegovy that was authorized by the FDA for weight administration. Wegovy additionally makes use of Semaglutide, the principle ingredient in Ozempic.

2. Weekly Injectables

As for Mounjaro vs Ozempic, each are weekly injectable drugs used to deal with kind 2 diabetes and function weight reduction drugs. They decrease blood sugar ranges by the incretin hormone pathway, suppress urge for food, and result in weight reduction.

3. Subcutaneous administration

Each medicine are administered subcutaneously and require dose titration (gradual addition of 1 answer of already recognized focus). These are essential as they will cut back gastrointestinal uncomfortable side effects similar to nausea, vomiting, and diarrhea.

“Additionally, each medicine advisable after the failure of first-line brokers, similar to metformin, exhibit favorable cardiovascular and metabolic profiles and aren’t appropriate for kind 1 diabetes,” says Dr Venkatalayaraju.

Mounjaro vs Ozempic: What is the distinction between them?

Some key variations between Mounjaro and Ozempic are:

1. Mounjarovs Ozempic: Elements and Mechanisms

Mounjaro (Tirzepatide) is a twin GIP/GLP-1 receptor agonist, whereas Ozempic (Semaglutide) targets GLP-1 receptors solely. This double concentrating on in Mounjaro has a probably optimistic impact on metabolism and might help you drop some weight.

2. Mounjarovs Ozempic: Dosage

Each are administered subcutaneously as soon as per week, however the doses differ. “Mounjaro is accessible in doses of two.5-15 mg every week, whereas Ozempic is normally titrated to 2 mg,” says an knowledgeable.

3. Mounjarovs Ozempic: Security

Launched within the US in 2017, Ozempic has broader long-term information, together with optimistic cardiovascular outcomes in kind 2 diabetes sufferers. “The long-term security of Munjaro continues to be being evaluated, however the early information is promising,” in response to Dr. Venkatarayaraju.

Mounjaro vs Ozempic: Which is healthier?

From a scientific efficacy perspective, Munjaro seems to be superior to Ozempic in each glycemic management and weight reduction. Throughout the research revealed in JAMA Inner Drugs, contributors who had been obese or overweight used tilzepatide and semaglutide. They skilled a big weight reduction when utilizing tilzepatide.

“However ‘higher’ additionally is dependent upon patient-specific components. Ozempic has sturdy cardiovascular information, together with FDA approval to cut back main cardiovascular occasions in high-risk folks. Mounjaro would not have this label but,” the knowledgeable says.

Within the battle between Mounjaro vs Ozempic, the previous could also be most popular if most weight reduction and glycemic management are the principle targets. If cardiovascular safety is a precedence, Ozempic could also be chosen.

Mounjaro vs Ozempic: Unintended effects

A number of the uncomfortable side effects embrace:

Unintended effects of Mounjaro

• Stomach bloating
• belly ache
• constipation
• bloating
• diarrhea
• nausea
• Lack of urge for food
• Discomfort and discoloration across the space the place the medication was injected

Unintended effects of Ozempic

• belly ache
• constipation
• diarrhea
• Indigestion
• Discomfort across the injection space

These uncomfortable side effects of Ozempic and Mounjaro could also be short-term, however there may be severe dangers. “They’re uncommon, however those that use each can have pancreatitis, thyroid tumors, and gallbladder illness,” specialists say.

There isn’t a clear winner within the Mounjaro vs Ozempic dialogue. Though their lively elements differ, their well being targets, uncomfortable side effects, and administration routes overlap significantly.